Dapsone compliance in North-east India.

Urine samples were collected from male staff memb ers o f the hospital who were not t aking dapsone , from male in-patients 2 4-h after their previous daily supervised dose of 1 00 mg dapsone and from male out-patients at the tim e of their visit to collect a further stock of 1 00 mg dapsone tablets for daily self­ administration . A small crystal o f thymol was then added to each urine sample and the samples stored without refrigeration at ambient temperatures of 7 5 ° to 1 00° F for 4 months until analysis in London. Urinary concentrations of diazotisab le compounds (as d apsone equivalents) were d etermined by a modification o f the Bratton and Marshall procedure , creatinine concentrations were determined using the alk aline picrate method , and 'dapsone/creatinine' ratios then calculated . 6